Post 14: Protein found may be involved in MS passing through the blood brain barrier
According to https://www.goodnewsnetwork.org/surprise-finding-could-lead-to-new-ms-treatments/
They found that peole with MS have more calnexin protein in their brains than other people. The thought is that if they can find a way to decrease calnexin, that it might be a way to prevent MS from passing through the blood brain barrier.
Mice studies seem to support the idea, but such results can be different with humans. Nevertheless, it is opening an important avenue, as there is much we do not understand about the blood brain barrier. I know that medications that allow vitamin B to cross the blood brain barrier, such as metafolbic and foltanx, have been helpful with neurological symptoms. Check with your medical doctor as to whether these medications could be helpful for you.
The brain is the last place you want MS to be at
My wife, Deborah Brogan, MD, was a board certified psychiatrist. We were married when she was 28 years old. She was not expected to live beyond the age of 40. She lived to be 61 years old and did private practice until she was 58 years old. She also worked at Arizona State University on their eating disorders team for 22 years after we were married. Prior to all of this, she worked at Albany County mental health clinic in albany, New York for 3 years. Prior to this, she spent seven years with medical school and a psychiatric residency.
She had severe juvenile diabetes since she was 12 years old. In 1998, 19 years before death in 2017, she had a kidney-pancreas transplant which was necessary because of the diabetes. She was hospitalized about 30 times, and continued working in between hospitalizations.
She was fond of the above “Elements of Resilience” and incorporated it into psychotherapy with her patients in private practice. It is good guidance in what to strive for to meet the challenges of life. It is a good summary of what helps me to cope with multiple sclerosis. It is the spirit I try to convey in my book, “Multiple Sclerosis Mission Remission: Healing MS Against All Odds” at
MS Post 12: We have come a long way, baby!
Stem cell treatments for multiple sclerosis is one of the newer success stories. See https://www.ncbi.nlm.nih.gov/m/pubmed/28621766/
Findings are that autologous haematopoietic stem cell transplantation will completely suppress MS disease activity for four or five years in seventy to eighty percent of people completing the procedure. That’s the good news.
The less fortunate news is that it works best on young ambulatory MS patients who have inflammatory activity going on in their brains, i.e. the multiple sclerosis is more active. So that probably rules me out.
Prior to 2005, there was a 3.6 percent mortality associated with this complex procedure. After 2005, the mortality was greatly reduced to only 0.3 percent.
I am older and very ambulatory with no inflammatory lesions or disease activity going on in my brain so I am probably not the best candidate for what sounds like an arduous procedure. I have achieved total remission with the help of a combination of different medical drugs with many healthy, alternative, and spiritual practices described in my book at
Post 11: When MS is hot, you are not well
For myself, I live in Phoenix, Arizona where temperatures in the summer are almost always over a 100ﾟF. During the hot summer months, the temperature in my closed garage is around a 120 ﾟF or more. I used to feel like somebody wound up and punched me when getting out of my car when my multiple sclerosis was active. Since my MS went into remission about ten years ago, The heat doesn’t affect me nearly as much.
Myelin helps nerve impulses travel faster down your nerve fibers. It is like the insulation covering an electrical cord. Because multiple sclerosis damages the myelin, the insulation covering your nerve fibers, the impulses travel slower. The damaged nerve fibers are especially susceptible to heat, and then conduct impulses even slower when it is hot for the person who has MS.
Read the story of the many things I did to go into remission from MS at
Curtain University found th as t eating fish and vegetables may be less likely to contract multiple sclerosis. Specifically, legumes, fish, vegetables, poultry and egg consumption correlated with less risk of getting MS.
Smoking, glandular fevers, getting less sun, and low vitamin D intake are known to be associated with increased risk of contracting multiple sclerosis.
The Australian study studied the difference between a healthy diet consisting of the above healthy foods and a tragically flawed Western diet (which typically includes too much sugar and fat).
The study’s author, Dr. Black concluded that people eating a high amount of these healthy foods, like fish and vegetables, were fifty percent less likely to contract multiple sclerosis than people who ate a low amount of these foods.
The reference for this study is:
Lucinda J Black et al. A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination, Multiple Sclerosis Journal (2018). DOI: 10.1177/1352458518793524
Read about my miracle MS remission at
The importance of vitamin D
I consider diet to be important to how well a person deals with MS. I eat a diet full of fruits and vegetables. I avoid gluten because I am allergic to it. The national health institute, after a review of the literature, highlights the importance of vitamin D. In what follows, I will be discussing their findings from the abstract at
Their findings emphasize the importance of vitamin D for MS people which is present and added to many foods including milk. Taking vitamin D supplements is recommended by neurolgists I know. You can also get vitamin D from the sun, because your body produces vitamin D when exposed to the sun. Moderation is key here because there is risk of increasing the chances of cancer if one gets sunburned or too much sun. Incidentally, vitamin D can also help one heal from sunburn, a full circle if you will.
Vitamin D is important because it is a potent modulator of the immune system. It is thought that getting enough vitamin D may prevent getting MS to some degree. It has long been noticed that people in northern latitudes, who get less sun and their bodies thus produce less vitamin D, are more likely to get MS.
The studies reviewed found that people with MS taking vitamin D were less likely to relapse and were less likely to have new lesions, the most significant marker of multiple sclerosis. Vitamin D improved brain lesions and improved walking speed, a significant indicator of the progression of the illness.
It has been found that MS people having a relapse typically have lower serum levels of vitamin D in their bodies, suggesting a preventative and possibly protective role for vitamin D in regard to multiple sclerosis. In any case, vitamin D should be an important vitamin to take through supplements because of its therapeutic effects. It is thought that it helps the MS body in its fight to repair MS damage.
To heal from MS, I believe one needs to use both alternative and medical approaches that are right for the person. You can see all the approaches I used in my book at
100 million people in the United States, or nearly a third of people in the United States, suffer from a neurological condition of which multiple sclerosis is one. Alzheimers, Parkinsons, dementia, ALS, brain tumors and conditions, traumatic brain injuries, migraine headaches, MS, chronic pain, stroke damage, genetic disorders, and epilepsy are among the thousand neurological conditions counted.
Over 500 new medications are in pharmaceutical companies drug development pipelines to treat neurological problems. Over seventy percent represent a brand new or “first in class” treatment approach.
In multiple sclerosis, the new candidate focuses on myelin repair. Myelin covers nerve fibers and is like insulation that allows the nerve signal to travel faster without interruption. It would help new myelin to grow to repair damaged nerve fibers.
There is nothing like this now, as the major MS medications are focused on preventing the immune system from mistakenly attacking the myelin protective sheath over the nerve fibers. These misguided attacks on the nerve fibers and brain neurons are why MS is considered to be an autoimmune disease.
Many of the alternative, spiritual, exercise, and healthy living approaches described in my book could help many people battling with chronic disease. See
I was interview #606 on psychologist Dr. David Van Nuys’ http://www.Shrinkrapradio.com
Gilenya was first pill for multiple sclerosis which was approved in 2010 for relapsing-remitting MS. In 2018 it was approved for use in children and adolescents. Another study found that it was a viable option for patients switching from Tysabri.
People often eventually switch from Tysabri to a different drug because they became JC positive. The JC virus is often latent in the brain, but if you become JC positive, new lesions could form on your brain.
In the study involving children and adolescents, Gilenya appeared to have the same or better results than people on Tysabri after two years. Gilenya is another option for people with multiple sclerosis. Its major advantage is that it has nothing to do with injection needles, because it’s a pill.
I have been on Ocrevus for seven months now, and so far, so good. Ocrevus is an infusion that you get once every six months. I will stick with Ocrevus because I have noticed that I respond better to infusions rather than pills. I believe this is because with pills, you are introducing another variable between yourself and the MS, which is your digestive system.
My digestive system must do something to medicines which is not a good thing. The infusion, I believe, leads to more direct treatment of the MS without having to go through my digestive system first.
Other people may experience different results because we are all different. Gilenya is another treatment option for MS patients which they can choose in consultation with their medical doctor.
Find a path to treatment of MS which can be individualized with consultation with your medical doctor. See https://www.amazon.com/gp/aw/d/B07D7JBZ5L/ref=cm_cr_othr_mb_bdcrb_top?ie=UTF8
This is my own very personal story of how my multiple sclerosis went into remission. It is an unlikely, but not impossible, event. Consult with your medical professional to find the best treatments for you which must be individualized because we are all different. I believe that recovery usually involves medical treatments with alternative treatments that are beneficial for that specific person.
Here are some of the rave reviews:
“Thank you for sharing your story Dr. Fox. As an incoming first year medical student, this book provided me with a unique perspective on the difficulties patient experience while dealing with diseases such as MS. In addition, it also helped me understand the importance of treating the patient rather than the disease. The use of precision medicine in the form of combination medicine is incredible. Again, thank you for sharing your personal life. I will recommend this book to all of my fellow colleagues!”
“Thank you Dr. Steven Fox for giving your audience a personal glimpse into your journey with MS. I finished the book cover to cover in a day and felt your pains as if they were my own and to witness how you found ways to heal and deal with your MS, abuse, loss brought me much enlightenment for my own journey.”
“This book has tons of MS information I never acknowledged or knew about. I thought this book was extremely helpful for those suffering from MS because it actually explains a real life experience from the author himself who recovered from MS. I would recommend to anyone who wanted first hand experience with MS.”
“This book had different approaches with dealing with MS and ways you can recover from MS that aren’t talked about publicly or that I have seen in other books or articles. This book really did make a difference of how I view life with MS.”
“I have a different outlook on a devastating disease. He gives hope and meaningful suggestions to conquer the beast of MS.”
“I love everything about this book!!!! Very useful information. Thank you, Dr Fox.”
I am humbled and grateful~Steven Fox Ph.D.