Mayzent is taken orally. It has been shown to slow the progression of disability progression in MS in people who are starting down the road of secondary progressive MS. This article gives the information. I still think that Ocrevus might be best although I know of no direct comparisons. I would like to see comparative studies or meta reviews of the efficacy of Ocrevus compared to Mayzent and other MS drugs. See
Lemtrada is a once a year infusion that may slow or possibly stop the progression of multiple sclerosis. It is a once a year infusion, but the first year you receive infusions for five days in a row. Subsequent infusions are once a year but occur for three days in a row.
Insurance companies paint it as being for relapsing-remitting multiple sclerosis, MS, after two ms drugs have failed. That is because there is some risk to the infusions.
It reminds me of the procedure used that stopped my MS in its tracks in the early 2000s. I was given big bags of steroids for three days in a row, which dampens the immune system, while also physically making your body stronger. On the third day the infusion included Cytoxan which modifies your immune system.
Because your body is revved on steroids, the immune system modification occurs quickly. This was done every three to six months, depending upon how I was reacting. It worked. My MS symptoms remitted, and have continued to improve until the present.
It is my guess that the Lemtrada may be working similarly. There was a lot of risk with the procedure I went through, and there is risk with Lemtrada. I believe it may be risky because both procedures basically turn your immune system off temporarily, followed by the immune system being less hyperactive about attacking your nervous system.
Both procedures use steroids heavily, which dampens the immune system. I had a severe infection after one set of infusions that landed me in the hospital for a week which I recovered from.
I continued to improve using once a week Tysabri self-injections, which I did for almost ten years; however, there is a danger to using Tysabri. The danger is that you may activate a latent JV virus which then causes multiple myelomas in your brain. They have a test that indicated I was getting close to JV virus activation, so I fortunately was able to switch to the new 800 pound gorilla in the fight against multiple sclerosis, Ocrevus.
The first time you take Ocrevus, it is infusions given two days in a row. The infusions last for six months. Subsequent infusions occur every six months and are for one day, with the infusion taking three or four hours.
My health has steadily improved since my late fifties. At 66, I am in better health than I was in my thirties. I developed MS in 1991 right before the first effective medications for multiple sclerosis were developed. Ocrevus is the best one by far. Tysabri helped a lot, but I noticed that I was more likely to get a cold or the flu on Tysabri. That has not been the case with Ocrevus. Ocrevus is for both primary progressive multiple sclerosis and relapsing remitting MS.
Actress Selma Blair describes the many years it took for her multiple sclerosis to be diagnosed in this interview:
She needs prednisolone infusions for the flare up. If I were her, I would use the once every six months infusion of Ocrevus. In any case, she should consult with her doctors regarding either of these possibilities as each case has its own unique features. She could avoid reinventing the wheel by reading my book “Multiple Sclerosis Mission Remission: Healing MS Against All Odds” which is available on amazon and is described at http://www.msmissionremission.com
Gilenya was first pill for multiple sclerosis which was approved in 2010 for relapsing-remitting MS. In 2018 it was approved for use in children and adolescents. Another study found that it was a viable option for patients switching from Tysabri.
People often eventually switch from Tysabri to a different drug because they became JC positive. The JC virus is often latent in the brain, but if you become JC positive, new lesions could form on your brain.
In the study involving children and adolescents, Gilenya appeared to have the same or better results than people on Tysabri after two years. Gilenya is another option for people with multiple sclerosis. Its major advantage is that it has nothing to do with injection needles, because it’s a pill.
I have been on Ocrevus for seven months now, and so far, so good. Ocrevus is an infusion that you get once every six months. I will stick with Ocrevus because I have noticed that I respond better to infusions rather than pills. I believe this is because with pills, you are introducing another variable between yourself and the MS, which is your digestive system.
My digestive system must do something to medicines which is not a good thing. The infusion, I believe, leads to more direct treatment of the MS without having to go through my digestive system first.
Other people may experience different results because we are all different. Gilenya is another treatment option for MS patients which they can choose in consultation with their medical doctor.
Find a path to treatment of MS which can be individualized with consultation with your medical doctor. See https://www.amazon.com/gp/aw/d/B07D7JBZ5L/ref=cm_cr_othr_mb_bdcrb_top?ie=UTF8
Ocrevus was approved by the FDA in March of 2017. It is the only medication approved for primary progressive multiple sclerosis although it can also be used for relapsing-remitting MS. It has a different method of dealing with the immune system.
Most MS drugs modify the T-cells of the immune system. Ocrevus is one of the only drugs that targets the myelin-attacking mature B cells.
Ocrevus changes the B cells of the immune system which is, so far, more successful.
Ocrevus slowed the progression of primary progressive MS, which is the most severe form of multiple sclerosis. It also reduces disease activity. It is always good to have things quiet down with MS.
Primary progressive MS affects about ten percent of people with multiple sclerosis. It’s the type of multiple sclerosis that I have. How it was sent into remission is described in my book at https://www.amazon.com/Multiple-Sclerosis-Mission-Remission-Healing-ebook/dp/B07D7JBZ5L/ref=mp_s_a_1_2?ie=UTF8&qid=1529367853&sr=8-2&pi=AC_SX236_SY340_FMwebp_QL65&keywords=multiple+sclerosis+Mission+remission