Lemtrada–Stopping the MS Attack?

Lemtrada is a once a year infusion that may slow or possibly stop the progression of multiple sclerosis. It is a once a year infusion, but the first year you receive infusions for five days in a row. Subsequent infusions are once a year but occur for three days in a row.

Insurance companies paint it as being for relapsing-remitting multiple sclerosis, MS, after two ms drugs have failed. That is because there is some risk to the infusions.

It reminds me of the procedure used that stopped my MS in its tracks in the early 2000s. I was given big bags of steroids for three days in a row, which dampens the immune system, while also physically making your body stronger. On the third day the infusion included Cytoxan which modifies your immune system.

Because your body is revved on steroids, the immune system modification occurs quickly. This was done every three to six months, depending upon how I was reacting. It worked. My MS symptoms remitted, and have continued to improve until the present.

It is my guess that the Lemtrada may be working similarly. There was a lot of risk with the procedure I went through, and there is risk with Lemtrada. I believe it may be risky because both procedures basically turn your immune system off temporarily, followed by the immune system being less hyperactive about attacking your nervous system.

Both procedures use steroids heavily, which dampens the immune system. I had a severe infection after one set of infusions that landed me in the hospital for a week which I recovered from.

I continued to improve using once a week Tysabri self-injections, which I did for almost ten years; however, there is a danger to using Tysabri. The danger is that you may activate a latent JV virus which then causes multiple myelomas in your brain. They have a test that indicated I was getting close to JV virus activation, so I fortunately was able to switch to the new 800 pound gorilla in the fight against multiple sclerosis, Ocrevus.

The first time you take Ocrevus, it is infusions given two days in a row. The infusions last for six months. Subsequent infusions occur every six months and are for one day, with the infusion taking three or four hours.

My health has steadily improved since my late fifties. At 66, I am in better health than I was in my thirties. I developed MS in 1991 right before the first effective medications for multiple sclerosis were developed. Ocrevus is the best one by far. Tysabri helped a lot, but I noticed that I was more likely to get a cold or the flu on Tysabri. That has not been the case with Ocrevus. Ocrevus is for both primary progressive multiple sclerosis and relapsing remitting MS.

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A pill for MS, Gilenya

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Gilenya was first pill for multiple sclerosis which was approved in 2010 for relapsing-remitting MS. In 2018 it was approved for use in children and adolescents. Another study found that it was a viable option for patients switching from Tysabri.

People often eventually switch from Tysabri to a different drug because they became JC positive. The JC virus is often latent in the brain, but if you become JC positive, new lesions could form on your brain.

In the study involving children and adolescents, Gilenya appeared to have the same or better results than people on Tysabri after two years. Gilenya is another option for people with multiple sclerosis. Its major advantage is that it has nothing to do with injection needles, because it’s a pill.

I have been on Ocrevus for seven months now, and so far, so good. Ocrevus is an infusion that you get once every six months. I will stick with Ocrevus because I have noticed that I respond better to infusions rather than pills. I believe this is because with pills, you are introducing another variable between yourself and the MS, which is your digestive system.

My digestive system must do something to medicines which is not a good thing. The infusion, I believe, leads to more direct treatment of the MS without having to go through my digestive system first.

Other people may experience different results because we are all different. Gilenya is another treatment option for MS patients which they can choose in consultation with their medical doctor.

Find a path to treatment of MS which can be individualized with consultation with your medical doctor. See https://www.amazon.com/gp/aw/d/B07D7JBZ5L/ref=cm_cr_othr_mb_bdcrb_top?ie=UTF8